4G0C

Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.

4G0C の概要

• エントリーDOI: 10.2210/pdb4g0c/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase, acetazolamide, hydrogen bonding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29220.29

構造登録者

Fisher, S.Z.,McKenna, R.,Aggarwal, M. (登録日: 2012-07-09, 公開日: 2012-09-19, 最終更新日: 2023-09-13)

• 主引用文献: Fisher, S.Z.,Aggarwal, M.,Kovalevsky, A.Y.,Silverman, D.N.,McKenna, R.; Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.; J.Am.Chem.Soc., 134:14726-14729, 2012; PubMed: 22928733; DOI: 10.1021/ja3068098

実験手法

NEUTRON DIFFRACTION (2 Å)