4FZI

Crystal structure of prostaglandin F synthase from Trypanosoma cruzi

4FZI の概要

• エントリーDOI: 10.2210/pdb4fzi/pdb
• 関連するPDBエントリー: 1VBJ 4F40
• 分子名称: Prostaglandin F synthase, GLUTAMIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, prostaglandin d2, trypanosomiasis, eukaryotic pathogen, parasite, nadp+, nadph, rutin, bimatoprost, oxidoreductase
• 由来する生物種: Trypanosoma cruzi
• 細胞内の位置: Cytoplasm : Q4DJ07
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67574.39

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2012-07-06, 公開日: 2012-07-18, 最終更新日: 2023-09-13)

主引用文献

Moen, S.O.,Fairman, J.W.,Barnes, S.R.,Sullivan, A.,Nakazawa-Hewitt, S.,Van Voorhis, W.C.,Staker, B.L.,Lorimer, D.D.,Myler, P.J.,Edwards, T.E.
Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
Acta Crystallogr F Struct Biol Commun, 71:609-614, 2015

PubMed Abstract: The crystal structures of prostaglandin F synthase (PGF) from both Leishmania major and Trypanosoma cruzi with and without their cofactor NADP have been determined to resolutions of 2.6 Å for T. cruzi PGF, 1.25 Å for T. cruzi PGF with NADP, 1.6 Å for L. major PGF and 1.8 Å for L. major PGF with NADP. These structures were determined by molecular replacement to a final R factor of less than 18.6% (Rfree of less than 22.9%). PGF in the infectious protozoa L. major and T. cruzi is a potential therapeutic target.

PubMed: 25945716
DOI: 10.1107/S2053230X15006883

実験手法

X-RAY DIFFRACTION (2.6 Å)