4FZF

Crystal structure of MST4-MO25 complex with DKI

Summary for 4FZF

• Entry DOI: 10.2210/pdb4fzf/pdb
• Related: 4FZA 4FZD
• Descriptor: Calcium-binding protein 39, Serine/threonine-protein kinase MST4, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE (3 entities in total)
• Functional Keywords: scaffold protein, protein ser/thr kinase, atp binding, signaling protein-transferase-inhibitor complex, signaling protein/transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm (Potential): Q9Y376; Cytoplasm: Q9P289
• Total number of polymer chains: 2
• Total formula weight: 70667.20

Authors

Shi, Z.B.,Zhou, Z.C. (deposition date: 2012-07-06, release date: 2013-03-06, Last modification date: 2023-11-08)

• Primary citation: Shi, Z.,Jiao, S.,Zhang, Z.,Ma, M.,Zhang, Z.,Chen, C.,Wang, K.,Wang, H.,Wang, W.,Zhang, L.,Zhao, Y.,Zhou, Z.; Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism; Structure, 21:449-461, 2013; PubMed: 23434407; DOI: 10.1016/j.str.2013.01.007

Experimental method

X-RAY DIFFRACTION (3.64 Å)