4FZF
Crystal structure of MST4-MO25 complex with DKI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calcium-binding protein 39 | polymer | 328 | 38311.1 | 1 | UniProt (Q9Y376) Pfam (PF08569) | Homo sapiens (human) | MO25alpha, Protein Mo25 |
| 2 | B (B) | Serine/threonine-protein kinase MST4 | polymer | 283 | 31930.7 | 1 | UniProt (Q9P289) Pfam (PF00069) | Homo sapiens (human) | Mammalian STE20-like protein kinase 4, MST-4, Mst3 and SOK1-related kinase, STE20-like kinase MST4, Serine/threonine-protein kinase MASK |
| 3 | C (B) | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | non-polymer | 425.4 | 1 | Chemie (DKI) |
Sequence modifications
A: 11 - 334 (UniProt: Q9Y376)
B: 18 - 297 (UniProt: Q9P289)
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Met 9 | - | expression tag |
| Ala 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | - | expression tag |
| Ala 16 | - | expression tag |
| Met 17 | - | expression tag |
| Ala 162 | Asp 162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70241.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 425.4 | |
| All* | Total formula weight | 70667.2 |
