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4FZC

20S yeast proteasome in complex with cepafungin I

Summary for 4FZC
Entry DOI10.2210/pdb4fzc/pdb
Related1RYP 2ZCY
Related PRD IDPRD_001018
DescriptorProteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywordsubiquitin, proteasome, drug development, inhibitor, natural product, n-terminal nucleophilic hydrolase, protein degradation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
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Total number of polymer chains32
Total formula weight706425.12
Authors
Stein, M.,Beck, P.,Kaiser, M.,Dudler, R.,Becker, C.F.W.,Groll, M. (deposition date: 2012-07-06, release date: 2012-10-24, Last modification date: 2023-11-15)
Primary citationStein, M.L.,Beck, P.,Kaiser, M.,Dudler, R.,Becker, C.F.,Groll, M.
One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.
Proc.Natl.Acad.Sci.USA, 109:18367-18371, 2012
Cited by
PubMed: 23091006
DOI: 10.1073/pnas.1211423109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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