4FX6
Crystal structure of the mutant V182A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Summary for 4FX6
Entry DOI | 10.2210/pdb4fx6/pdb |
Related | 3LTP 4FX6 4FX8 4FXR |
Descriptor | Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | tim barrel, inhibitor bmp, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Methanothermobacter thermautotrophicus str. Delta H |
Total number of polymer chains | 2 |
Total formula weight | 50589.80 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. (deposition date: 2012-07-02, release date: 2013-05-22, Last modification date: 2023-09-13) |
Primary citation | Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629DOI: 10.1021/bi301188k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.531 Å) |
Structure validation
Download full validation report