4FWU

Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4

4FWU の概要

• エントリーDOI: 10.2210/pdb4fwu/pdb
• 関連するPDBエントリー: 4F9U 4F9V
• 分子名称: CG32412, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• 機能のキーワード: alpha/beta hydrolase, pglu formation, alzheimer`s disease, pyroglutamate, pglu-amyloid, glycosylation, hydrolase
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36660.14

構造登録者

Kolenko, P.,Koch, B.,Stubbs, M.T. (登録日: 2012-07-02, 公開日: 2012-09-05, 最終更新日: 2024-11-06)

主引用文献

Kolenko, P.,Koch, B.,Rahfeld, J.U.,Schilling, S.,Demuth, H.U.,Stubbs, M.T.
Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
Acta Crystallogr.,Sect.F, 69:358-361, 2013

PubMed Abstract: The structure of ligand-free glutaminyl cyclase (QC) from Drosophila melanogaster (DmQC) has been determined in a novel crystal form. The protein crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 Å. The crystal diffracted to a resolution of 2 Å at the home source. The structure was solved by molecular replacement and was refined to an R factor of 0.169. DmQC exhibits a typical α/β-hydrolase fold. The electron density of three monosaccharides could be localized. The accessibility of the active site will facilitate structural studies of novel inhibitor-binding modes.

PubMed: 23545638
DOI: 10.1107/S1744309113005575

実験手法

X-RAY DIFFRACTION (2 Å)