4FW0

Structure of rat nNOS heme domain in complex with N(delta)-methyl- N(omega)-hydroxy-L-arginine

Summary for 4FW0

Related4FVW 4FVX 4FVY 4FVZ
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, substrate analog
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein  P29476
Total number of polymer chains2
Total molecular weight99932.47
Authors
Li, H.,Poulos, T.L. (deposition date: 2012-06-29, release date: 2013-05-15, Last modification date: 2017-11-15)
Primary citation
Jansen Labby, K.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52:3062-3073, 2013
PubMed: 23586781 (PDB entries with the same primary citation)
DOI: 10.1021/bi301571v
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243302.6%11.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution