4FU6

Crystal structure of the PSIP1 PWWP domain

4FU6 の概要

• エントリーDOI: 10.2210/pdb4fu6/pdb
• 分子名称: PC4 and SFRS1-interacting protein, SULFATE ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : O75475
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17898.66

構造登録者

Qin, S.,Tempel, W.,Xu, C.,Wu, H.,Dong, A.,Cerovina, T.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2012-06-28, 公開日: 2012-08-29, 最終更新日: 2023-09-13)

主引用文献

Qin, S.,Min, J.
Structure and function of the nucleosome-binding PWWP domain.
Trends Biochem.Sci., 39:536-547, 2014

PubMed Abstract: PWWP domain-containing proteins are often involved in chromatin-associated biological processes, such as transcriptional regulation and DNA repair, and recent studies have shown that the PWWP domain specifies chromatin localization. Mutations in the PWWP domain, a 100-150 amino acid motif, have been linked to various human diseases, emphasizing its importance. Structural studies reveal that PWWP domains possess a conserved aromatic cage for histone methyl-lysine recognition, and synergistically bind both histone and DNA, which contributes to their nucleosome-binding ability and chromatin localization. Furthermore, the PWWP domain often cooperates with other histone and DNA 'reader' or 'modifier' domains to evoke crosstalk between various epigenetic marks. Here, we discuss these recent advances in understanding the structure and function of the PWWP domain.

PubMed: 25277115
DOI: 10.1016/j.tibs.2014.09.001

実験手法

X-RAY DIFFRACTION (2.1 Å)