4FS1

Base pairing mechanism of N2,3-ethenoguanine with dTTP by human polymerase iota

Summary for 4FS1

• Entry DOI: 10.2210/pdb4fs1/pdb
• Related: 3OSN 3V6H 3V6J 3V6K 4FS2
• Descriptor: DNA 5'-D(*TP*CP*TP*(EFG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: human dna polymerase iota, dna polymerase, dna replication, lesion bypass, 2'-fluoro arabinose, n2, 3-ethenoguanine, dttp, template, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9UNA4
• Total number of polymer chains: 3
• Total formula weight: 58674.55

Authors

Zhao, L. (deposition date: 2012-06-26, release date: 2012-08-29, Last modification date: 2024-02-28)

• Primary citation: Zhao, L.,Pence, M.G.,Christov, P.P.,Wawrzak, Z.,Choi, J.Y.,Rizzo, C.J.,Egli, M.,Guengerich, F.P.; Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases.; J.Biol.Chem., 287:35516-35526, 2012; PubMed: 22910910; DOI: 10.1074/jbc.M112.403253

Experimental method

X-RAY DIFFRACTION (2.5 Å)