4FRU

Crystal structure of horse wild-type cyclophilin B

Summary for 4FRU

Entry DOI	10.2210/pdb4fru/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase, ZINC ION, 1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE, ... (5 entities in total)
Functional Keywords	cyclophilin-type ppiase, peptidyl-prolyl cis-trans isomerase; chaperone; foldase, p3h1-crtap-cypb complex; lh1 binding, endoplasmic reticulum, isomerase
Biological source	Equus caballus (domestic horse,equine)
Total number of polymer chains	1
Total formula weight	20850.66
Authors	Boudko, S.P.,Ishikawa, Y.,Bachinger, H.P. (deposition date: 2012-06-26, release date: 2012-11-14, Last modification date: 2023-09-13)
Primary citation	Boudko, S.P.,Ishikawa, Y.,Lerch, T.F.,Nix, J.,Chapman, M.S.,Bachinger, H.P. Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse. BMC Res Notes, 5:626-626, 2012 Cited by PubMed Abstract: Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B. PubMed: 23137129 DOI: 10.1186/1756-0500-5-626 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation