4FQS

Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed

4FQS の概要

• エントリーDOI: 10.2210/pdb4fqs/pdb
• 関連するPDBエントリー: 3QJ7 4FOA 4FOG 4FOX
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, folate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61240.85

構造登録者

Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C. (登録日: 2012-06-25, 公開日: 2013-08-07, 最終更新日: 2024-02-28)

• 主引用文献: Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition; To be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)