4FNZ

Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2

Summary for 4FNZ

Entry DOI	10.2210/pdb4fnz/pdb
Related	4DCE 4FNW 4FNX 4FNY 4FOB 4FOC 4FOD
Descriptor	ALK tyrosine kinase receptor, (3S)-N-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide (3 entities in total)
Functional Keywords	receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, cd246, phosphotransferase, npm-alk, eml4-alk, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : Q9UM73
Total number of polymer chains	1
Total formula weight	37394.76
Authors	Whittington, D.A.,Epstein, L.F.,Chen, H. (deposition date: 2012-06-20, release date: 2012-08-29, Last modification date: 2024-02-28)
Primary citation	Epstein, L.F.,Chen, H.,Emkey, R.,Whittington, D.A. The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. J.Biol.Chem., 287:37447-37457, 2012 Cited by PubMed: 22932897 DOI: 10.1074/jbc.M112.391425 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation