4FNZ
Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK tyrosine kinase receptor | polymer | 327 | 36833.2 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | A | (3S)-N-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | non-polymer | 561.6 | 1 | Chemie (NZF) | |||
| 3 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 1084 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 1097 | Cys 1097 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36833.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 561.6 | |
| All* | Total formula weight | 37394.8 |
