Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4FNY

Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor

Summary for 4FNY
Entry DOI10.2210/pdb4fny/pdb
Related4FNW 4FNX 4FNZ 4FOB 4FOC 4FOD
DescriptorALK tyrosine kinase receptor, N-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, cd246, phosphotransferase, npm-alk, eml4-alk, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein: Q9UM73
Total number of polymer chains1
Total formula weight37252.01
Authors
Whittington, D.A.,Epstein, L.F.,Chen, H. (deposition date: 2012-06-20, release date: 2012-08-29, Last modification date: 2024-02-28)
Primary citationEpstein, L.F.,Chen, H.,Emkey, R.,Whittington, D.A.
The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase.
J.Biol.Chem., 287:37447-37457, 2012
Cited by
PubMed: 22932897
DOI: 10.1074/jbc.M112.391425
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon