4FNW
Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain
Summary for 4FNW
Entry DOI | 10.2210/pdb4fnw/pdb |
Related | 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD |
Descriptor | ALK tyrosine kinase receptor, GLYCEROL (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, cd246, phosphotransferase, npm-alk, eml4-alk, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 36983.38 |
Authors | Whittington, D.A.,Epstein, L.F.,Chen, H. (deposition date: 2012-06-20, release date: 2012-08-29, Last modification date: 2024-02-28) |
Primary citation | Epstein, L.F.,Chen, H.,Emkey, R.,Whittington, D.A. The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. J.Biol.Chem., 287:37447-37457, 2012 Cited by PubMed: 22932897DOI: 10.1074/jbc.M112.391425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report