4FNW
Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 327 | 36799.2 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A: 1084 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 1097 | Cys 1097 | engineered mutation |
| Leu 1174 | Phe 1174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36799.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 184.2 | |
| All* | Total formula weight | 36983.4 |
