4FMU
Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF
Summary for 4FMU
Entry DOI | 10.2210/pdb4fmu/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD2, ZINC ION, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, ... (5 entities in total) |
Functional Keywords | structural genomics consortium, sgc, methyltransferase, set domain-containing protein 2, pr-snf, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q9BYW2 |
Total number of polymer chains | 1 |
Total formula weight | 32575.18 |
Authors | Dong, A.,Zeng, H.,Ibanez, G.,Zheng, W.,Tempel, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Luo, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-18, release date: 2012-09-05, Last modification date: 2023-09-13) |
Primary citation | Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M. Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134:18004-18014, 2012 Cited by PubMed: 23043551DOI: 10.1021/ja307060p PDB entries with the same primary citation |
Experimental method |
Structure validation
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