4FIK

Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products

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4FIK の概要

関連するPDBエントリー2OSF
分子名称Carbonic anhydrase 2, ZINC ION, 2,4-dihydroxybenzenesulfenic acid, ... (8 entities in total)
機能のキーワードcarbonic anhydrase ii, human carbonic anhydrase ii, hca ii, hca2, ca ii, ca2, carbonate dehydratase ii, carbonic anhydrase c, thioxolone, 4-mercaptobenzene-1, 3-diol, 4-(2, 4-dihydroxyphenyl) disulfanylbenzene-1, disease mutation, lyase, metal-binding
由来する生物種Homo sapiens (human)
ポリマー鎖数1
分子量合計30200.42
構造登録者
Sippel, K.H.,Genis, C.,Govindasamy, L.,Agbandje-McKenna, M.,Tripp, B.C.,McKenna, R. (登録日: 2012-06-08, 公開日: 2012-06-27, 最終更新日: 2019-07-17)
主引用文献
Sippel, K.H.,Genis, C.,Govindasamy, L.,Agbandje-McKenna, M.,Kiddle, J.J.,Tripp, B.C.,McKenna, R.
Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
J Phys Chem Lett, 1:2898-2902, 2010
PubMed: 20976122 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jz100954h
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.14930 1.4% 3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード