4FI8

Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide

4FI8 の概要

• エントリーDOI: 10.2210/pdb4fi8/pdb
• 関連するPDBエントリー: 3HJ0 4FI6 4FI7
• 分子名称: Transthyretin, 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride (3 entities in total)
• 機能のキーワード: hormone, binding protein, covalent kinetic stabilizer, hormone-hormone inhibitor complex, hormone/hormone inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28490.88

構造登録者

Connelly, S.,Grimster, N.,Wilson, I.A.,Kelly, J.W. (登録日: 2012-06-08, 公開日: 2013-02-20, 最終更新日: 2023-09-13)

• 主引用文献: Grimster, N.P.,Connelly, S.,Baranczak, A.,Dong, J.,Krasnova, L.B.,Sharpless, K.B.,Powers, E.T.,Wilson, I.A.,Kelly, J.W.; Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.; J.Am.Chem.Soc., 135:5656-5668, 2013; PubMed: 23350654; DOI: 10.1021/ja311729d

実験手法

X-RAY DIFFRACTION (1.22 Å)