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4FHH

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

Summary for 4FHH
Entry DOI10.2210/pdb4fhh/pdb
Related4FHI
DescriptorVitamin D3 receptor A, Nuclear receptor coactivator 2, N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, ... (4 entities in total)
Functional Keywordsligand binding domain, apha helical sandwich, alpha helical sandwich, transcription factor, adn coregulators, phosphorylation and hdac inhibitor, nucleus, transcription-protein binding-inhibitor complex, transcription/protein binding/inhibitor
Biological sourceDanio rerio (leopard danio,zebra danio,zebra fish)
More
Cellular locationNucleus: Q9PTN2 Q15596
Total number of polymer chains2
Total formula weight35954.01
Authors
Fischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L. (deposition date: 2012-06-06, release date: 2012-09-19, Last modification date: 2024-02-28)
Primary citationFischer, J.,Wang, T.T.,Kaldre, D.,Rochel, N.,Moras, D.,White, J.H.,Gleason, J.L.
Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.
Chem.Biol., 19:963-971, 2012
Cited by
PubMed: 22921063
DOI: 10.1016/j.chembiol.2012.05.024
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

217705

건을2024-03-27부터공개중

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