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4FHH

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 0U3 A 501
ChainResidue
ATYR175
AARG302
ASER303
ASER306
ACYS316
ATYR323
AVAL328
AHIS333
AHIS423
ALEU430
ALEU255
AALA259
ALEU261
AVAL262
ATYR264
ASER265
AILE299
AMET300

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:17218092, ECO:0000269|PubMed:17346665
ChainResidueDetails
ATYR175
ALEU255
AILE299
AHIS333
AHIS423

218853

PDB entries from 2024-04-24

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