4FGY
Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity
Summary for 4FGY
Entry DOI | 10.2210/pdb4fgy/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, ... (4 entities in total) |
Functional Keywords | ppar lbd, nuclear receptor fold, ligand binding, gene transcription, transcription-transferase-antibiotic complex, transcription/transferase/antibiotic |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32990.60 |
Authors | |
Primary citation | Zheng, W.,Feng, X.,Qiu, L.,Pan, Z.,Wang, R.,Lin, S.,Hou, D.,Jin, L.,Li, Y. Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56:401-411, 2013 Cited by PubMed: 23178929DOI: 10.1007/s00125-012-2777-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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