4FGY

Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 0W3 A 601

Chain	Residue
A	ALA306
A	MET357
A	LEU358
A	LEU361
A	ILE369
A	LEU381
A	PHE391
A	MET392
A	HIS477
A	HOH710
A	ILE309
A	PHE310
A	CYS313
A	GLN314
A	ARG316
A	SER317
A	ILE354
A	TYR355

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG

Chain	Residue	Details
A	GLN314
A	HIS351
A	HIS477
A	TYR501

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	LYS252

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