4FGL
Reduced quinone reductase 2 in complex with chloroquine
Summary for 4FGL
Entry DOI | 10.2210/pdb4fgl/pdb |
Related | 4FGJ 4FGK |
Descriptor | Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | chloroquine, fmn reductase superfamily (conserved domain database), metallo-flavoprotein, rossmann fold, two-electron reduction of quinones to hydroquinones, fad binding, zn binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P16083 |
Total number of polymer chains | 4 |
Total formula weight | 109437.86 |
Authors | Leung, K.K.,Shilton, B.H. (deposition date: 2012-06-04, release date: 2013-03-13, Last modification date: 2023-09-13) |
Primary citation | Leung, K.K.,Shilton, B.H. Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction J.Biol.Chem., 2013 |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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