4FGL

Reduced quinone reductase 2 in complex with chloroquine

Summary for 4FGL

• Entry DOI: 10.2210/pdb4fgl/pdb
• Related: 4FGJ 4FGK
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: chloroquine, fmn reductase superfamily (conserved domain database), metallo-flavoprotein, rossmann fold, two-electron reduction of quinones to hydroquinones, fad binding, zn binding, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 4
• Total formula weight: 109437.86

Authors

Leung, K.K.,Shilton, B.H. (deposition date: 2012-06-04, release date: 2013-03-13, Last modification date: 2023-09-13)

• Primary citation: Leung, K.K.,Shilton, B.H.; Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction; J.Biol.Chem., 2013

Experimental method

X-RAY DIFFRACTION (1.2 Å)