4FFX

Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation

4FFX の概要

• エントリーDOI: 10.2210/pdb4ffx/pdb
• 関連するPDBエントリー: 2J91 2VD6 4FFQ
• 分子名称: Adenylosuccinate lyase (2 entities in total)
• 機能のキーワード: purine biosynthesis, lyase, disease mutation, purine metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 221094.25

構造登録者

Deaton, M.K.,Ray, S.P.,Capodagli, G.C.,Calkins, L.A.F.,Sawle, L.,Ghosh, K.,Patterson, D.,Pegan, S.D. (登録日: 2012-06-01, 公開日: 2012-08-01, 最終更新日: 2023-09-13)

• 主引用文献: Ray, S.P.,Deaton, M.K.,Capodagli, G.C.,Calkins, L.A.,Sawle, L.,Ghosh, K.,Patterson, D.,Pegan, S.D.; Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.; Biochemistry, 51:6701-6713, 2012; PubMed: 22812634; DOI: 10.1021/bi300796y

実験手法

X-RAY DIFFRACTION (2.7 Å)