4FFS

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A

Summary for 4FFS

Entry DOI	10.2210/pdb4ffs/pdb
Descriptor	MTA/SAH nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, hydrolase activity, acting on glycosyl bonds, hydrolase
Biological source	Helicobacter pylori
Total number of polymer chains	1
Total formula weight	26657.19
Authors	Haapalainen, A.M.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. (deposition date: 2012-06-01, release date: 2012-09-26, Last modification date: 2024-02-28)
Primary citation	Wang, S.,Haapalainen, A.M.,Yan, F.,Du, Q.,Tyler, P.C.,Evans, G.B.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori. Biochemistry, 51:6892-6894, 2012 Cited by PubMed: 22891633 DOI: 10.1021/bi3009664 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation