4FFS
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A
4FFS の概要
エントリーDOI | 10.2210/pdb4ffs/pdb |
分子名称 | MTA/SAH nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, ... (4 entities in total) |
機能のキーワード | l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, hydrolase activity, acting on glycosyl bonds, hydrolase |
由来する生物種 | Helicobacter pylori |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 26657.19 |
構造登録者 | Haapalainen, A.M.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. (登録日: 2012-06-01, 公開日: 2012-09-26, 最終更新日: 2024-02-28) |
主引用文献 | Wang, S.,Haapalainen, A.M.,Yan, F.,Du, Q.,Tyler, P.C.,Evans, G.B.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori. Biochemistry, 51:6892-6894, 2012 Cited by PubMed: 22891633DOI: 10.1021/bi3009664 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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