4FFS

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A

4FFS の概要

• エントリーDOI: 10.2210/pdb4ffs/pdb
• 分子名称: MTA/SAH nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, hydrolase activity, acting on glycosyl bonds, hydrolase
• 由来する生物種: Helicobacter pylori
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26657.19

構造登録者

Haapalainen, A.M.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L. (登録日: 2012-06-01, 公開日: 2012-09-26, 最終更新日: 2024-02-28)

• 主引用文献: Wang, S.,Haapalainen, A.M.,Yan, F.,Du, Q.,Tyler, P.C.,Evans, G.B.,Rinaldo-Matthis, A.,Brown, R.L.,Norris, G.E.,Almo, S.C.,Schramm, V.L.; A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori.; Biochemistry, 51:6892-6894, 2012; PubMed: 22891633; DOI: 10.1021/bi3009664

実験手法

X-RAY DIFFRACTION (1.9 Å)