4FEQ

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Summary for 4FEQ

Entry DOI	10.2210/pdb4feq/pdb
Related	3QUP 4FF8
Descriptor	Tyrosine-protein kinase receptor TYRO3, 4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide (3 entities in total)
Functional Keywords	protein kinase domain, receptor tyrosine kinase, gas6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (mouse)
Cellular location	Cell membrane; Single-pass type I membrane protein: P55144
Total number of polymer chains	1
Total formula weight	37223.01
Authors	Ohren, J.F.,Powell, N.A.,Kohrt, J.T.,Perrin, L.A. (deposition date: 2012-05-30, release date: 2013-03-13, Last modification date: 2024-02-28)
Primary citation	Powell, N.A.,Hoffman, J.K.,Ciske, F.L.,Kaufman, M.D.,Kohrt, J.T.,Quin, J.,Sheehan, D.J.,Delaney, A.,Baxi, S.M.,Catana, C.,McConnell, P.,Ohren, J.,Perrin, L.A.,Edmunds, J.J. Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg.Med.Chem.Lett., 23:1046-1050, 2013 Cited by PubMed: 23312472 DOI: 10.1016/j.bmcl.2012.12.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation