4FEQ

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase receptor TYRO3	polymer	323	36771.4	1	UniProt (P55144) Pfam (PF07714) In PDB	Mus musculus (mouse)	Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE
2	A	4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide	non-polymer		451.6	1	Chemie (0T8)
3		water	water		18.0	35	Chemie (HOH)

Sequence modifications

A: 485 - 800 (UniProt: P55144)

PDB	External Database	Details
Met 484	-	initiating methionine
His 801	-	expression tag
His 802	-	expression tag
His 803	-	expression tag
His 804	-	expression tag
His 805	-	expression tag
His 806	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36771.4
Non-Polymers*	Number of molecules	1
	Total formula weight	451.6
All*	Total formula weight	37223.0

*Water molecules are not included.