4FEA

Crystal structure of CASPASE-7 in Complex with allosteric inhibitor

Summary for 4FEA

• Entry DOI: 10.2210/pdb4fea/pdb
• Related: 4FDL
• Descriptor: Caspase-7, chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1H)-ylidene-kappaN)methyl]carbonodithiohydrazonate}copper (2 entities in total)
• Functional Keywords: cysteine protease, apoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P55210
• Total number of polymer chains: 2
• Total formula weight: 56946.60

Authors

Kabaleeswaran, V. (deposition date: 2012-05-29, release date: 2012-08-01, Last modification date: 2023-09-13)

• Primary citation: Feldman, T.,Kabaleeswaran, V.,Jang, S.B.,Antczak, C.,Djaballah, H.,Wu, H.,Jiang, X.; A class of allosteric caspase inhibitors identified by high-throughput screening.; Mol.Cell, 47:585-595, 2012; PubMed: 22795132; DOI: 10.1016/j.molcel.2012.06.007

Experimental method

X-RAY DIFFRACTION (3.79 Å)