4FDI
The molecular basis of mucopolysaccharidosis IV A
Summary for 4FDI
Entry DOI | 10.2210/pdb4fdi/pdb |
Related | 4FDJ |
Descriptor | N-acetylgalactosamine-6-sulfatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | glycoprotein, enzyme replacement therapy, sulfatase, formylglycine, n-linked glycosylation, lysosomal enzyme, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P34059 |
Total number of polymer chains | 2 |
Total formula weight | 114136.28 |
Authors | Rivera-Colon, Y.,Garman, S.C. (deposition date: 2012-05-28, release date: 2012-09-05, Last modification date: 2023-12-06) |
Primary citation | Rivera-Colon, Y.,Schutsky, E.K.,Kita, A.Z.,Garman, S.C. The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A. J.Mol.Biol., 423:736-751, 2012 Cited by PubMed: 22940367DOI: 10.1016/j.jmb.2012.08.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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