4FDH

Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole

Summary for 4FDH

Entry DOI	10.2210/pdb4fdh/pdb
Related	4DVQ
Descriptor	Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile, ... (4 entities in total)
Functional Keywords	cytochrome p450, cyp11b2, aldosterone synthase, monooxygenase, heme protein, mineralocorticoid, inhibitor, mitochondria, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion membrane: P19099
Total number of polymer chains	12
Total formula weight	677871.12
Authors	Strushkevich, N.,Shen, L.,Tempel, W.,Arrowsmith, C.,Edwards, A.,Usanov, S.A.,Park, H.-W. (deposition date: 2012-05-28, release date: 2013-01-30, Last modification date: 2024-02-28)
Primary citation	Strushkevich, N.,Gilep, A.A.,Shen, L.,Arrowsmith, C.H.,Edwards, A.M.,Usanov, S.A.,Park, H.W. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Mol.Endocrinol., 27:315-324, 2013 Cited by PubMed: 23322723 DOI: 10.1210/me.2012-1287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation