4FAP
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
Summary for 4FAP
| Entry DOI | 10.2210/pdb4fap/pdb |
| Related | 2FAP 3FAP |
| Descriptor | FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN, C15-(R)-METHYLTHIENYL RAPAMYCIN (3 entities in total) |
| Functional Keywords | fkbp12, frap, rapamycin, complex, gene therapy, cell cycle |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm, cytosol : P62942 Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345 |
| Total number of polymer chains | 2 |
| Total formula weight | 24148.74 |
| Authors | Liang, J.,Clardy, J. (deposition date: 1999-05-06, release date: 2000-09-13, Last modification date: 2023-09-13) |
| Primary citation | Liang, J.,Choi, J.,Clardy, J. Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55:736-744, 1999 Cited by PubMed: 10089303DOI: 10.1107/S0907444998014747 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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