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4F9M

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Summary for 4F9M
Entry DOI10.2210/pdb4f9m/pdb
Related3B1M 3LMP 3V9T 3V9V 3V9Y
DescriptorPeroxisome proliferator-activated receptor gamma, peptide from Nuclear receptor coactivator 1, (9aS)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total)
Functional Keywordsthree-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P37231
Nucleus (By similarity): Q15788
Total number of polymer chains2
Total formula weight34720.18
Authors
Matsui, Y.,Hanzawa, H. (deposition date: 2012-05-19, release date: 2012-08-08, Last modification date: 2023-11-08)
Primary citationFurukawa, A.,Arita, T.,Fukuzaki, T.,Mori, M.,Honda, T.,Satoh, S.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Nakamura, K.,Araki, K.,Kuroha, M.,Tanaka, J.,Wakimoto, S.,Suzuki, O.,Ohsumi, J.
Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators
Eur.J.Med.Chem., 54:522-533, 2012
Cited by
PubMed: 22727448
DOI: 10.1016/j.ejmech.2012.05.040
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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