4F9M
Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator
Summary for 4F9M
Entry DOI | 10.2210/pdb4f9m/pdb |
Related | 3B1M 3LMP 3V9T 3V9V 3V9Y |
Descriptor | Peroxisome proliferator-activated receptor gamma, peptide from Nuclear receptor coactivator 1, (9aS)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total) |
Functional Keywords | three-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 34720.18 |
Authors | Matsui, Y.,Hanzawa, H. (deposition date: 2012-05-19, release date: 2012-08-08, Last modification date: 2023-11-08) |
Primary citation | Furukawa, A.,Arita, T.,Fukuzaki, T.,Mori, M.,Honda, T.,Satoh, S.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Nakamura, K.,Araki, K.,Kuroha, M.,Tanaka, J.,Wakimoto, S.,Suzuki, O.,Ohsumi, J. Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators Eur.J.Med.Chem., 54:522-533, 2012 Cited by PubMed: 22727448DOI: 10.1016/j.ejmech.2012.05.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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