4F9M

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

4F9M の概要

• エントリーDOI: 10.2210/pdb4f9m/pdb
• 関連するPDBエントリー: 3B1M 3LMP 3V9T 3V9V 3V9Y
• 分子名称: Peroxisome proliferator-activated receptor gamma, peptide from Nuclear receptor coactivator 1, (9aS)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: three-layered alpha-helical sandwich, transcription regulation, transcription-transcription regulator complex, transcription/transcription regulator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34720.18

構造登録者

Matsui, Y.,Hanzawa, H. (登録日: 2012-05-19, 公開日: 2012-08-08, 最終更新日: 2023-11-08)

• 主引用文献: Furukawa, A.,Arita, T.,Fukuzaki, T.,Mori, M.,Honda, T.,Satoh, S.,Matsui, Y.,Wakabayashi, K.,Hayashi, S.,Nakamura, K.,Araki, K.,Kuroha, M.,Tanaka, J.,Wakimoto, S.,Suzuki, O.,Ohsumi, J.; Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators; Eur.J.Med.Chem., 54:522-533, 2012; PubMed: 22727448; DOI: 10.1016/j.ejmech.2012.05.040

実験手法

X-RAY DIFFRACTION (1.9 Å)