4F6V

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1034, mg2+ and fmp.

4F6V の概要

• エントリーDOI: 10.2210/pdb4f6v/pdb
• 分子名称: Dehydrosqualene synthase, 2,4-dioxo-4-{[3-(3-phenoxyphenyl)propyl]amino}butanoic acid, S,R MESO-TARTARIC ACID, ... (6 entities in total)
• 機能のキーワード: transferase, dehydrosqualene synthase, bph-1034, diketo acid, virulence factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35558.82

構造登録者

Lin, F.-Y.,Zhang, Y.,Liu, Y.-L.,Oldfield, E. (登録日: 2012-05-15, 公開日: 2012-06-13, 最終更新日: 2024-02-28)

• 主引用文献: Zhang, Y.,Lin, F.-Y.,Li, K.,Zhu, W.,Liu, Y.L.,Cao, R.,Pang, R.,Lee, E.,Axelson, J.,Hensler, M.,Wang, K.,Molohon, K.J.,Wang, Y.,Mitchell, D.A.,Nizet, V.,Oldfield, E.; HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.; ACS Med Chem Lett, 3:402-406, 2012; PubMed: 22662288; DOI: 10.1021/ml300038t

実験手法

X-RAY DIFFRACTION (2.3 Å)