4F4P
SYK in COMPLEX WITH LIGAND LASW836
Summary for 4F4P
Entry DOI | 10.2210/pdb4f4p/pdb |
Descriptor | Tyrosine-protein kinase SYK, N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | tyrosine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 32088.89 |
Authors | Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (deposition date: 2012-05-11, release date: 2012-12-12, Last modification date: 2024-02-28) |
Primary citation | Castillo, M.,Forns, P.,Erra, M.,Mir, M.,Lopez, M.,Maldonado, M.,Orellana, A.,Carreno, C.,Ramis, I.,Miralpeix, M.,Vidal, B. Highly potent aminopyridines as Syk kinase inhibitors. Bioorg.Med.Chem.Lett., 22:5419-5423, 2012 Cited by PubMed: 22877633DOI: 10.1016/j.bmcl.2012.07.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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