4F4P

SYK in COMPLEX WITH LIGAND LASW836

4F4P の概要

• エントリーDOI: 10.2210/pdb4f4p/pdb
• 分子名称: Tyrosine-protein kinase SYK, N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tyrosine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane : P43405
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32088.89

構造登録者

Lopez, M.,Segarra, V.,Vidal, B.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M.,Nagel, S.,Schreiner, P. (登録日: 2012-05-11, 公開日: 2012-12-12, 最終更新日: 2024-02-28)

主引用文献

Castillo, M.,Forns, P.,Erra, M.,Mir, M.,Lopez, M.,Maldonado, M.,Orellana, A.,Carreno, C.,Ramis, I.,Miralpeix, M.,Vidal, B.
Highly potent aminopyridines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22:5419-5423, 2012

PubMed Abstract: A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2-pyridyl motif and represented by compound 13b IC(50): 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.

PubMed: 22877633
DOI: 10.1016/j.bmcl.2012.07.045

実験手法

X-RAY DIFFRACTION (2.37 Å)