4F45

Crystal structure of human CD38 E226Q mutant in complex with NAADP

Summary for 4F45

• Entry DOI: 10.2210/pdb4f45/pdb
• Related: 4F46
• Descriptor: ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate (3 entities in total)
• Functional Keywords: cd38, adp-ribosyl cyclase, naadp, calcium signaling, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type II membrane protein: P28907
• Total number of polymer chains: 2
• Total formula weight: 61112.29

Authors

Zhang, H.,Lee, H.C.,Hao, Q. (deposition date: 2012-05-10, release date: 2013-04-03)

• Primary citation: Zhang, H.,Graeff, R.,Lee, H.C.,Hao, Q.; Crystal Structures of Human CD38 in Complex with NAADP and ADPRP; MESSENGER, 2:44-53, 2013

Experimental method

X-RAY DIFFRACTION (2.1 Å)