4F2T

Modulation of S.aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding.

4F2T の概要

• エントリーDOI: 10.2210/pdb4f2t/pdb
• 関連するPDBエントリー: 3V16 3V18 3V1H 4F2B 4F2U
• 分子名称: 1-phosphatidylinositol phosphodiesterase, ACETATE ION (3 entities in total)
• 機能のキーワード: alpha beta barrel, phosphatidylinostol-specific phospholipase c, membrane interface, lyase
• 由来する生物種: Staphylococcus aureus subsp. aureus
• 細胞内の位置: Secreted: P45723
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35343.18

構造登録者

Cheng, J.,Goldstein, R.,Stec, B.,Gershenson, A.,Roberts, M.F. (登録日: 2012-05-08, 公開日: 2012-12-12, 最終更新日: 2023-09-13)

主引用文献

Cheng, J.,Goldstein, R.,Stec, B.,Gershenson, A.,Roberts, M.F.
Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287:40317-40327, 2012

PubMed Abstract: Bacterial phosphatidylinositol-specific phospholipase C targets PI and glycosylphosphatidylinositol-linked proteins of eukaryotic cells.

PubMed: 23038258
DOI: 10.1074/jbc.M112.395277

実験手法

X-RAY DIFFRACTION (2.3 Å)