4F0F

Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum

4F0F の概要

• エントリーDOI: 10.2210/pdb4f0f/pdb
• 関連するPDBエントリー: 4F0G 4F1M 4F1O 4F1T
• 分子名称: Serine/threonine-protein kinase roco4, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER (3 entities in total)
• 機能のキーワード: protein kinase, lrrk2, roco, kinase, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Dictyostelium discoideum (Slime mold)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33121.75

構造登録者

Gilsbach, B.K.,Vetter, I.R.,Wittinghofer, A.,Kortholt, A. (登録日: 2012-05-04, 公開日: 2012-06-27, 最終更新日: 2023-09-13)

• 主引用文献: Gilsbach, B.K.,Ho, F.Y.,Vetter, I.R.,van Haastert, P.J.,Wittinghofer, A.,Kortholt, A.; Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.; Proc.Natl.Acad.Sci.USA, 109:10322-10327, 2012; PubMed: 22689969; DOI: 10.1073/pnas.1203223109

実験手法

X-RAY DIFFRACTION (1.8 Å)