4F0E

Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102

4F0E の概要

• エントリーDOI: 10.2210/pdb4f0e/pdb
• 関連するPDBエントリー: 3BLJ 3GEY
• 分子名称: Poly [ADP-ribose] polymerase 15, 8-methyl-2-[(pyrimidin-2-ylsulfanyl)methyl]quinazolin-4(1H)-one (3 entities in total)
• 機能のキーワード: artd, parp, poly (adp-ribose) polymerase, adp-ribose, bal3, b-aggressive lymphoma protein 3, transferase, glycosyltransferase, nucleus, transcription, transcription regulation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Probable): Q460N3
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92724.15

構造登録者

Karlberg, T.,Andersson, C.D.,Lindgren, A.,Thorsell, A.G.,Ekblad, T.,Spjut, S.,Weigelt, J.,Elofsson, M.,Linusson, A.,Schuler, H. (登録日: 2012-05-04, 公開日: 2012-09-05, 最終更新日: 2024-05-29)

• 主引用文献: Andersson, C.D.,Karlberg, T.,Ekblad, T.,Lindgren, A.E.,Thorsell, A.G.,Spjut, S.,Uciechowska, U.,Niemiec, M.S.,Wittung-Stafshede, P.,Weigelt, J.,Elofsson, M.,Schuler, H.,Linusson, A.; Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.; J.Med.Chem., 55:7706-7718, 2012; PubMed: 22823910; DOI: 10.1021/jm300746d

実験手法

X-RAY DIFFRACTION (2.4 Å)