4EYW

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone

4EYW の概要

• エントリーDOI: 10.2210/pdb4eyw/pdb
• 分子名称: Carnitine O-palmitoyltransferase 2, mitochondrial, 1-[(2R)-2-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)piperidin-1-yl]-2-phenoxyethanone, HEXAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: acyltransferase, mitochondrial protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : P18886
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 144387.37

構造登録者

Rudolph, M.G.,Benz, J.,Burger, D.,Thoma, R.,Rufer, A.,Joseph, C. (登録日: 2012-05-02, 公開日: 2013-04-24, 最終更新日: 2024-04-03)

• 主引用文献: Perspicace, S.,Rufer, A.C.,Thoma, R.,Mueller, F.,Hennig, M.,Ceccarelli, S.,Schulz-Gasch, T.,Seelig, J.; Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein.; FEBS Open Bio, 3:204-211, 2013; PubMed: 23772395; DOI: 10.1016/j.fob.2013.04.003

実験手法

X-RAY DIFFRACTION (1.885 Å)