4EVY

Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin

4EVY の概要

• エントリーDOI: 10.2210/pdb4evy/pdb
• 分子名称: Aminoglycoside N(6')-acetyltransferase type 1, TOBRAMYCIN, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: center for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, gnat superfamily, gcn5-related n-acetyltransferase superfamily, n-acetyltransferase fold, antibiotic resistance, acetyl coenzyme a, intracellular, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Acinetobacter haemolyticus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38918.17

構造登録者

Stogios, P.J.,Evdokimova, E.,Minasov, G.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-04-26, 公開日: 2012-05-09, 最終更新日: 2023-09-13)

• 主引用文献: Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Law, M.,Courvalin, P.,Savchenko, A.; Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.; ACS Infect Dis., 3:132-143, 2017; PubMed: 27785912; DOI: 10.1021/acsinfecdis.6b00058

実験手法

X-RAY DIFFRACTION (1.768 Å)