4EUZ

Crystal structure of serratia fonticola carbapenemase SFC-1 S70A-Meropenem complex

Summary for 4EUZ

Entry DOI	10.2210/pdb4euz/pdb
Related	4EQI 4EV4
Descriptor	Carbapenem-hydrolizing beta-lactamase SFC-1, (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	carbapenemase, hydrolase, antibiotic resistance, beta-lactamase complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Serratia fonticola
Total number of polymer chains	1
Total formula weight	31602.43
Authors	Fonseca, F.,Spencer, J. (deposition date: 2012-04-25, release date: 2012-05-23, Last modification date: 2023-09-13)
Primary citation	Fonseca, F.,Chudyk, E.I.,van der Kamp, M.W.,Correia, A.,Mulholland, A.J.,Spencer, J. The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations. J.Am.Chem.Soc., 134:18275-18285, 2012 Cited by PubMed: 23030300 DOI: 10.1021/ja304460j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.08 Å)

Structure validation