4EU2

Crystal structure of 20s proteasome with novel inhibitor K-7174

4EU2 の概要

• エントリーDOI: 10.2210/pdb4eu2/pdb
• 分子名称: Proteasome component C7-alpha, Proteasome component PUP3, Proteasome component C11, ... (16 entities in total)
• 機能のキーワード: proteasome inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P21243 P25451 P22141 P30656 P23724 P30657 P23639 P23638 P40303 P32379 P40302 P21242 P38624 P25043
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 707188.29

構造登録者

Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Ohki, M.,Sugiyama, K.,Park, S.-Y.,Furukawa, Y. (登録日: 2012-04-25, 公開日: 2013-05-01, 最終更新日: 2024-03-20)

• 主引用文献: Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Sugiyama, K.,Ohki, M.,Park, S.Y.,Furukawa, Y.; Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.; Plos One, 8:e60649-e60649, 2013; PubMed: 23593271; DOI: 10.1371/journal.pone.0060649

実験手法

X-RAY DIFFRACTION (2.509 Å)