4ESR
Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors
Summary for 4ESR
Entry DOI | 10.2210/pdb4esr/pdb |
Descriptor | Jouberin, DI(HYDROXYETHYL)ETHER (3 entities in total) |
Functional Keywords | ahi-1, ahi1, ahi-1 sh3 domain, sh3 domain, dynamin-2, protein binding, chronic myeloid leukemia |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, cilium basal body : Q8N157 |
Total number of polymer chains | 2 |
Total formula weight | 16227.67 |
Authors | Van Petegem, X.F.,Liu, P.X.,Lobo, P.,Jiang, X. (deposition date: 2012-04-23, release date: 2012-06-06, Last modification date: 2024-02-28) |
Primary citation | Liu, X.,Chen, M.,Lobo, P.,An, J.,Grace Cheng, S.W.,Moradian, A.,Morin, G.B.,Van Petegem, F.,Jiang, X. Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors. Proteomics, 12:2094-2106, 2012 Cited by PubMed: 22623184DOI: 10.1002/pmic.201100553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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