4EQU

Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7

4EQU の概要

• エントリーDOI: 10.2210/pdb4equ/pdb
• 分子名称: Serine/threonine-protein kinase 10, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: serine/threonine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Peripheral membrane protein: O94804
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70178.98

構造登録者

Merritt, E.A.,Larson, E.T. (登録日: 2012-04-19, 公開日: 2012-11-07, 最終更新日: 2012-12-19)

• 主引用文献: Ranjitkar, P.,Perera, B.G.,Swaney, D.L.,Hari, S.B.,Larson, E.T.,Krishnamurty, R.,Merritt, E.A.,Villen, J.,Maly, D.J.; Affinity-Based Probes Based on Type II Kinase Inhibitors.; J.Am.Chem.Soc., 134:19017-19025, 2012; PubMed: 23088519; DOI: 10.1021/ja306035v

実験手法

X-RAY DIFFRACTION (2 Å)